Paris Saint-Germain, last season’s battered finalists, face Barcelona in the 16-year-old in the Champions League while Liverpool were paired with RB Leipzig in Monday’s draw.
Bayern Munich, who beat PSG in the 2020 final to win a sixth European crown, play Lazio in the knockout phase.
Pep Guardiola’s Manchester City team, who are still looking for a first Champions League title, must get past Borussia Moenchengladbach.
Chelsea, winner in 2012, has a tough task against Atletico Madrid.
Cristiano Ronaldo and Juventus will play against Portuguese Porto, the 2004 winner, while Real Madrid face last season’s surprising quarter-finalists Atalanta.
PSG will enjoy another chance to avenge their self-destructive defeat against Barcelona in 2017.
After beating the Catalans 4-0 in the French capital, PSG crashed to a 6-1 defeat at the Camp Nou, orchestrated by Neymar. The Brazilian joined PSG in a world record move weeks later.
With the matches to be played in February, PSG hope Neymar will have recovered from an ankle injury that forced him to be carried off the pitch in a 1-0 defeat in Ligue 1 against Lyon on Sunday.
Liverpool will be wary of an attack-minded Leipzig side that ended Manchester United’s hopes in the group stage.